Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gna15tm1Tmw
Name:	guanine nucleotide binding protein, alpha 15; targeted mutation 1, Thomas M Wilkie
MGI ID:	MGI:2152420
Gene:	Gna15  Location: Chr10:81338140-81360059 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Gna15tm1Tmw page

Germline Transmission:	Earliest citation of germline transmission: J:59992
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 8kb of sequence that contains exons 3 through 6. The sequences encode three of the five amino acid motifs which are essential for guanine nucleotide binding to the alpha subunit. Western blot analysis did not detect any protein produced from this allele in extracts derived from spleen, thymus, lymph nodes or lungs of homozygous mutant mice. (J:59992)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna15 Mutation:	31 strains or lines available

Original:	J:59992 Davignon I, et al., Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. Mol Cell Biol. 2000 Feb;20(3):797-804
All:	5 reference(s)