Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dnah1tm1Ihgg
Name:	dynein, axonemal, heavy chain 1; targeted mutation 1, Institut fur Humangenetik
MGI ID:	MGI:2151944
Synonyms:	MDHC7-
Gene:	Dnah1  Location: Chr14:30982332-31045853 bp, - strand  Genetic Position: Chr14, Syntenic
Alliance:	Dnah1tm1Ihgg page

Germline Transmission:	Earliest citation of germline transmission: J:69800
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Four exons encoding the P1-loop region are replaced by a neomycin cassette. Northern blot analysis did not detect a transcript produced from this allele and western blot analysis did not detect DNAHC1 protein in extracts of testis or oviducts from homozygous mice. (J:69800)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnah1 Mutation:	168 strains or lines available

Original:	J:69800 Neesen J, et al., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet. 2001 May 15;10(11):1117-28
All:	2 reference(s)