Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Hoxa5tm1Rob
Name:	homeobox A5; targeted mutation 1, Elizabeth J Robertson
MGI ID:	MGI:2150397
Synonyms:	Hoxa5-
Gene:	Hoxa5  Location: Chr6:52178768-52181437 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa5tm1Rob page

Germline Transmission:	Earliest citation of germline transmission: J:15576
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette into exon 2 disrupted sequences that encode the DNA binding homeodomain. Northern analysis using an exon 2 probe detected novel transcripts and no wild-type transcripts in lung and kidney of homozygous mutant mice. (J:71563)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	217 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

List all tumor models in MMHCdb carrying Hoxa5tm1Rob

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxa5 Mutation:	27 strains or lines available

Original:	J:15576 Jeannotte L, et al., Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene. Genes Dev. 1993 Nov;7(11):2085-96
All:	25 reference(s)