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Grin3b Gene Detail
Summary
  • Symbol
    Grin3b
  • Name
    glutamate receptor, ionotropic, NMDA3B
  • Synonyms
    NR3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150393
    NCBI Gene: 170483
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr10:79806549-79813024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150393
 protein coding gene Chr10:79806227-79813024 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017474
 protein coding gene Chr10:80542086-80548555 (+)
A/J MGP_AJ_G0017452
 protein coding gene Chr10:77726909-77733377 (+)
AKR/J MGP_AKRJ_G0017413
 protein coding gene Chr10:79844405-79850880 (+)
BALB/cJ MGP_BALBcJ_G0017414
 protein coding gene Chr10:77953995-77960470 (+)
C3H/HeJ MGP_C3HHeJ_G0017237
 protein coding gene Chr10:79950489-79956964 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017868
 protein coding gene Chr10:83323963-83330434 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015556
 protein coding gene Chr10:73952327-73959299 (+)
CAST/EiJ MGP_CASTEiJ_G0016804
 protein coding gene Chr10:80146510-80153023 (+)
CBA/J MGP_CBAJ_G0017209
 protein coding gene Chr10:86551475-86557950 (+)
DBA/2J MGP_DBA2J_G0017315
 protein coding gene Chr10:76943334-76949809 (+)
FVB/NJ MGP_FVBNJ_G0017309
 protein coding gene Chr10:76122724-76129199 (+)
LP/J MGP_LPJ_G0017386
 protein coding gene Chr10:81019040-81025515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017335
 protein coding gene Chr10:88514809-88521277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017909
 protein coding gene Chr10:79833835-79840310 (+)
PWK/PhJ MGP_PWKPhJ_G0016585
 protein coding gene Chr10:76809421-76815975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016374
 protein coding gene Chr10:78804561-78811024 (+)
WSB/EiJ MGP_WSBEiJ_G0016864
 protein coding gene Chr10:79856499-79862991 (+)



Homology
more
  • Human Ortholog
    GRIN3B, glutamate ionotropic receptor NMDA type subunit 3B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN3B, glutamate ionotropic receptor NMDA type subunit 3B
  • Synonyms
    GluN3B, NR3B
  • Links
    NCBI Gene ID: 116444
    neXtProt AC: NX_O60391
    UniProt: O60391

  • Chr Location
    19p13.3; chr19:1000419-1009732 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show a mild impairment in motor learning or coordination, reduced home cage activity, a highly increased social interaction with familiar cagemates in their home cage but moderately increased anxiety-like behavior and reduced social interaction in a new environment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    37
  • cDNA Data
    6
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035745 Ensembl Gene Model | MGI Sequence Detail 6476 C57BL/6J ±  kb
    transcript ENSMUST00000045085 Ensembl | MGI Sequence Detail 3283 Not Applicable  
    polypeptide ENSMUSP00000048576 Ensembl | MGI Sequence Detail 1003 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008251 glutamate receptor ionotropic, NMDA 3B
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:335422 Spirkova A, et al., Glutamate can act as a signaling molecule in mouse preimplantation embryos. Biol Reprod. 2022 Oct 11;107(4):916-927
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory