Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxa4tm1Mrc
Name:	homeobox A4; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:2150391
Synonyms:	hoxa-4-
Gene:	Hoxa4  Location: Chr6:52166662-52168683 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa4tm1Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:19219
Parent Cell Line:	CC1.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 1.5 kb of genomic DNA between sequences that encode the recognition helix of the homeodomain and a point 3' to the stop codon. No mRNA was detected by RT-PCR analysis on RNA derived from E12.5 embryos. (J:19219)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa4 Mutation:	8 strains or lines available

Original:	J:19219 Kostic D, et al., Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev. 1994 Jun;46(3):231-47
All:	1 reference(s)