Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp5tm1Ask
Name:	aquaporin 5; targeted mutation 1, Alan S Verkman
MGI ID:	MGI:2150059
Synonyms:	AQP5-
Gene:	Aqp5  Location: Chr15:99488909-99492710 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance:	Aqp5tm1Ask page

Germline Transmission:	Earliest citation of germline transmission: J:56302
Parent Cell Line:	CB1-4 (ES Cell)
Strain of Origin:	C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.8kb neomycin resistance cassette replaced parts of exon 2 and 4, all of exon 3, and all of introns 2 and 3. Northern blots of submandibular gland homogenates from homozygous mutant mice showed no detectable full-length Aqp5 transcripts. Immunocytochemistry of the salivary glands from homozygous mutant mice showed no detectable Aqp5 protein. (J:56302)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:	16 strains or lines available

Original:	J:56302 Ma T, et al., Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999 Jul 16;274(29):20071-4
All:	19 reference(s)