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Cygb Gene Detail
Summary
  • Symbol
    Cygb
  • Name
    cytoglobin
  • Synonyms
    3110001K20Rik, Staap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149481
    NCBI Gene: 114886
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116536421-116544887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.45 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149481
 protein coding gene Chr11:116536421-116545139 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019434
 protein coding gene Chr11:120789582-120799765 (-)
A/J MGP_AJ_G0019402
 protein coding gene Chr11:115500312-115509162 (-)
AKR/J MGP_AKRJ_G0019373
 protein coding gene Chr11:118936902-118945629 (-)
BALB/cJ MGP_BALBcJ_G0019377
 protein coding gene Chr11:115896404-115905427 (-)
C3H/HeJ MGP_C3HHeJ_G0019183
 protein coding gene Chr11:119294797-119305453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019826
 protein coding gene Chr11:124485045-124494561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017450
 protein coding gene Chr11:112513781-112522513 (-)
CAST/EiJ MGP_CASTEiJ_G0018738
 protein coding gene Chr11:120672884-120681866 (-)
CBA/J MGP_CBAJ_G0019154
 protein coding gene Chr11:129398979-129411465 (-)
DBA/2J MGP_DBA2J_G0019266
 protein coding gene Chr11:114925929-114934971 (-)
FVB/NJ MGP_FVBNJ_G0019258
 protein coding gene Chr11:114437089-114445771 (-)
LP/J MGP_LPJ_G0019336
 protein coding gene Chr11:121173401-121183194 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019291
 protein coding gene Chr11:128435066-128443888 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019865
 protein coding gene Chr11:119599610-119609531 (-)
PWK/PhJ MGP_PWKPhJ_G0018502
 protein coding gene Chr11:116254341-116263051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018295
 protein coding gene Chr11:119351701-119360352 (-)
WSB/EiJ MGP_WSBEiJ_G0018790
 protein coding gene Chr11:119568989-119577668 (-)



Homology
more
  • Human Ortholog
    CYGB, cytoglobin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYGB, cytoglobin
  • Synonyms
    HGB, STAP
  • Links
    NCBI Gene ID: 114757
    neXtProt AC: NX_Q8WWM9
    UniProt: Q8WWM9

  • Chr Location
    17q25.1; chr17:76527356-76551193 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display increased sensitivity to chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    99
  • cDNA Data
    50
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114886 NCBI Gene Model | MGI Sequence Detail 8467 C57BL/6J ±  kb
    transcript NM_001418165 RefSeq | MGI Sequence Detail 2090 C57BL/6  
    polypeptide Q9CX80 UniProt | EBI | MGI Sequence Detail 190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 51
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926136
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345134 Zweier JL, et al., Cytoglobin has potent superoxide dismutase function. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory