Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adra1btm1Cta
Name:	adrenergic receptor, alpha 1b; targeted mutation 1, Susanna Cotecchia
MGI ID:	MGI:2148638
Synonyms:	alpha1b-, alpha1b-AR-
Gene:	Adra1b  Location: Chr11:43665433-43792037 bp, - strand  Genetic Position: Chr11, 25.81 cM
Alliance:	Adra1btm1Cta page

Germline Transmission:	Earliest citation of germline transmission: J:43591
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 1 was deleted and replaced with a neomycin selection cassette. RT-PCR analysis confirmed that no transcript is produced from this allele. (J:43591)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra1b Mutation:	18 strains or lines available

Original:	J:43591 Cavalli A, et al., Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11589-94
All:	29 reference(s)