Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdh5tm1Pec
Name:	cadherin 5; targeted mutation 1, Peter Carmeliet
MGI ID:	MGI:2148547
Synonyms:	VECneo
Gene:	Cdh5  Location: Chr8:104828257-104871143 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Cdh5tm1Pec page

Germline Transmission:	Earliest citation of germline transmission: J:56509
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A stop codon was introduced into the coding sequence in front of the sequences encoding the 82 carboxy-terminal residues. A loxP-flanked neomycin selection cassette was also inserted into intron 11. Western blot analysis on endothelial cells derived from homozygous mice confirmed that no detectable protein was made. (J:56509)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:	53 strains or lines available

Original:	J:56509 Carmeliet P, et al., Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57
All:	1 reference(s)