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Ffar4 Gene Detail
Summary
  • Symbol
    Ffar4
  • Name
    free fatty acid receptor 4
  • Synonyms
    Ffa4, Gpr120, Gpr129, O3far1, Pgr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147577
    NCBI Gene: 107221
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38085527-38102711 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147577
 protein coding gene Chr19:38085519-38102711 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025087
 protein coding gene Chr19:37115084-37134834 (+)
A/J MGP_AJ_G0025063
 protein coding gene Chr19:35314909-35332509 (+)
AKR/J MGP_AKRJ_G0025031
 protein coding gene Chr19:36516379-36534005 (+)
BALB/cJ MGP_BALBcJ_G0025061
 protein coding gene Chr19:35420795-35441120 (+)
C3H/HeJ MGP_C3HHeJ_G0024820
 protein coding gene Chr19:36587030-36606523 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025502
 protein coding gene Chr19:38181981-38198995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022921
 protein coding gene Chr19:34669815-34688042 (+)
CAST/EiJ MGP_CASTEiJ_G0024287
 protein coding gene Chr19:36458150-36475213 (+)
CBA/J MGP_CBAJ_G0024797
 protein coding gene Chr19:39961070-39980235 (+)
DBA/2J MGP_DBA2J_G0024929
 protein coding gene Chr19:35168174-35186323 (+)
FVB/NJ MGP_FVBNJ_G0024890
 protein coding gene Chr19:34977221-34999065 (+)
LP/J MGP_LPJ_G0025015
 protein coding gene Chr19:37213696-37232474 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024921
 protein coding gene Chr19:39739249-39760934 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025560
 protein coding gene Chr19:36615141-36632794 (+)
PWK/PhJ MGP_PWKPhJ_G0024039
 protein coding gene Chr19:35033967-35052075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023839
 protein coding gene Chr19:35452968-35469828 (+)
WSB/EiJ MGP_WSBEiJ_G0024354
 protein coding gene Chr19:36694969-36715444 (+)



Homology
more
  • Human Ortholog
    FFAR4, free fatty acid receptor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FFAR4, free fatty acid receptor 4
  • Synonyms
    BMIQ10, GPR120, GPR129, GT01, O3FAR1, OB10Q, PGR4
  • Links
    NCBI Gene ID: 338557
    neXtProt AC: NX_Q5NUL3
    UniProt: Q5NUL3

  • Chr Location
    10q23.33; chr10:93566665-93604480 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FFAR4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 5 genetic backgrounds
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    18
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107221 NCBI Gene Model | MGI Sequence Detail 17185 C57BL/6J ±  kb
    transcript NM_181748 RefSeq | MGI Sequence Detail 1393 C57BL/6  
    polypeptide Q7TMA4 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 2
      Gene Ontology 21
      Phenotypes 52
    • Earliest
      J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
    • Latest
      J:337784 Zhang N, et al., FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome. J Lipid Res. 2023 Apr 17;64(6):100374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory