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Slc39a3 Gene Detail
Summary
  • Symbol
    Slc39a3
  • Name
    solute carrier family 39 (zinc transporter), member 3
  • Synonyms
    MGC:7461, zip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147269
    NCBI Gene: 106947
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80864374-80873169 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147269
 protein coding gene Chr10:80864372-80873260 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017532
 protein coding gene Chr10:81704866-81713748 (-)
A/J MGP_AJ_G0017510
 protein coding gene Chr10:78823258-78832130 (-)
AKR/J MGP_AKRJ_G0017471
 protein coding gene Chr10:80986367-80995282 (-)
BALB/cJ MGP_BALBcJ_G0017472
 protein coding gene Chr10:79038233-79047125 (-)
C3H/HeJ MGP_C3HHeJ_G0017295
 protein coding gene Chr10:81068838-81077706 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017926
 protein coding gene Chr10:84512759-84524493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015615
 protein coding gene Chr10:75028504-75037598 (-)
CAST/EiJ MGP_CASTEiJ_G0016862
 protein coding gene Chr10:81308620-81317302 (-)
CBA/J MGP_CBAJ_G0017267
 protein coding gene Chr10:87809169-87818013 (-)
DBA/2J MGP_DBA2J_G0017373
 protein coding gene Chr10:78017855-78026784 (-)
FVB/NJ MGP_FVBNJ_G0017367
 protein coding gene Chr10:77258572-77267405 (-)
LP/J MGP_LPJ_G0017444
 protein coding gene Chr10:82157059-82166423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017393
 protein coding gene Chr10:89680698-89689592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017967
 protein coding gene Chr10:80980012-80988875 (-)
PWK/PhJ MGP_PWKPhJ_G0016643
 protein coding gene Chr10:77915699-77925921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016433
 protein coding gene Chr10:79929005-79937912 (-)
WSB/EiJ MGP_WSBEiJ_G0016922
 protein coding gene Chr10:81017678-81026365 (-)



Homology
more
  • Human Ortholog
    SLC39A3, solute carrier family 39 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A3, solute carrier family 39 member 3
  • Synonyms
    ZIP3, ZIP-3
  • Links
    NCBI Gene ID: 29985
    neXtProt AC: NX_Q9BRY0
    UniProt: Q9BRY0

  • Chr Location
    19p13.3; chr19:2732204-2740076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice stressed with a zinc-deficient diet during pregnancy or at weaning exhibit a subtle increase in the sensitivity to abnormal morphogenesis of the embryo and to depletion of thymic pre-T cells, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    952
  • Tissues
    152
  • cDNA Data
    55
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106947 NCBI Gene Model | MGI Sequence Detail 8796 C57BL/6J ±  kb
transcript NM_134135 RefSeq | MGI Sequence Detail 3687 C57BL/6  
polypeptide Q99K24 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    cDNA 56

    Microarray probesets 5
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:337461 Elgheznawy A, et al., Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Front Immunol. 2023;14:1197894
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory