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Stap2 Gene Detail
Summary
  • Symbol
    Stap2
  • Name
    signal transducing adaptor family member 2
  • Synonyms
    STAP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147039
    NCBI Gene: 106766
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56304077-56312584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147039
 protein coding gene Chr17:56304074-56315558 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023906
 protein coding gene Chr17:57617878-57626640 (-)
A/J MGP_AJ_G0023866
 protein coding gene Chr17:56068272-56076596 (-)
AKR/J MGP_AKRJ_G0023835
 protein coding gene Chr17:56752611-56761560 (-)
BALB/cJ MGP_BALBcJ_G0023867
 protein coding gene Chr17:55903251-55911941 (-)
C3H/HeJ MGP_C3HHeJ_G0023630
 protein coding gene Chr17:57459658-57469424 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024311
 protein coding gene Chr17:59902178-59910701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021758
 protein coding gene Chr17:52586245-52594896 (-)
CAST/EiJ MGP_CASTEiJ_G0023113
 protein coding gene Chr17:57763902-57772156 (-)
CBA/J MGP_CBAJ_G0023607
 protein coding gene Chr17:62199353-62213609 (-)
DBA/2J MGP_DBA2J_G0023735
 protein coding gene Chr17:54802550-54810977 (-)
FVB/NJ MGP_FVBNJ_G0023701
 protein coding gene Chr17:54317864-54326604 (-)
LP/J MGP_LPJ_G0023815
 protein coding gene Chr17:58342467-58352380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023728
 protein coding gene Chr17:61768276-61778235 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024356
 protein coding gene Chr17:57127295-57137554 (-)
PWK/PhJ MGP_PWKPhJ_G0022858
 protein coding gene Chr17:54144190-54154477 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022670
 protein coding gene Chr17:53890354-53904116 (-)
WSB/EiJ MGP_WSBEiJ_G0023177
 protein coding gene Chr17:57738657-57749716 (-)



Homology
more
  • Human Ortholog
    STAP2, signal transducing adaptor family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAP2, signal transducing adaptor family member 2
  • Synonyms
    BKS
  • Links
    NCBI Gene ID: 55620
    neXtProt AC: NX_Q9UGK3
    UniProt: Q9UGK3

  • Chr Location
    19p13.3; chr19:4324043-4342786 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and display no apparent abnormalities in most organs at the gross and histological level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    66
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038781 Ensembl Gene Model | MGI Sequence Detail 8508 C57BL/6J ±  kb
transcript ENSMUST00000043785 Ensembl | MGI Sequence Detail 1509 Not Applicable  
polypeptide ENSMUSP00000038130 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 5
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:82584 Minoguchi M, et al., STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem. 2003 Mar 28;278(13):11182-9
  • Latest
    J:344981 Saitoh K, et al., STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals. J Immunol. 2022 Jul 1;209(1):57-68
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory