About   Help   FAQ
Ttbk1 Gene Detail
Summary
  • Symbol
    Ttbk1
  • Name
    tau tubulin kinase 1
  • Synonyms
    C330008L01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147036
    NCBI Gene: 106763
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46753374-46798601 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147036
 protein coding gene Chr17:46751577-46798601 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023817
 protein coding gene Chr17:47493575-47540618 (-)
A/J MGP_AJ_G0023775
 protein coding gene Chr17:46362685-46408590 (-)
AKR/J MGP_AKRJ_G0023746
 protein coding gene Chr17:46705134-46750203 (-)
BALB/cJ MGP_BALBcJ_G0023779
 protein coding gene Chr17:46262184-46310541 (-)
C3H/HeJ MGP_C3HHeJ_G0023542
 protein coding gene Chr17:47445530-47491009 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024222
 protein coding gene Chr17:49554438-49600850 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021672
 protein coding gene Chr17:43153160-43198316 (-)
CAST/EiJ MGP_CASTEiJ_G0023024
 protein coding gene Chr17:47523027-47571852 (-)
CBA/J MGP_CBAJ_G0023519
 protein coding gene Chr17:51331286-51376408 (-)
DBA/2J MGP_DBA2J_G0023645
 protein coding gene Chr17:45143498-45189333 (-)
FVB/NJ MGP_FVBNJ_G0023612
 protein coding gene Chr17:44756470-44802417 (-)
LP/J MGP_LPJ_G0023726
 protein coding gene Chr17:48184065-48230185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023641
 protein coding gene Chr17:50888662-50935919 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024267
 protein coding gene Chr17:47057629-47103693 (-)
PWK/PhJ MGP_PWKPhJ_G0022769
 protein coding gene Chr17:44479024-44524178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022584
 protein coding gene Chr17:43931348-43980748 (-)
WSB/EiJ MGP_WSBEiJ_G0023089
 protein coding gene Chr17:47603427-47651681 (-)



Homology
more
  • Human Ortholog
    TTBK1, tau tubulin kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTBK1, tau tubulin kinase 1
  • Synonyms
    BDTK
  • Links
    NCBI Gene ID: 84630
    neXtProt AC: NX_Q5TCY1
    UniProt: Q5TCY1

  • Chr Location
    6p21.1; chr6:43243481-43288258 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    11
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015599 Ensembl Gene Model | MGI Sequence Detail 45228 C57BL/6J ±  kb
    transcript ENSMUST00000047034 Ensembl | MGI Sequence Detail 6959 Not Applicable  
    polypeptide ENSMUSP00000044580 Ensembl | MGI Sequence Detail 1308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146972
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory