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Srl Gene Detail
Summary
  • Symbol
    Srl
  • Name
    sarcalumenin
  • Synonyms
    9830004M20Rik, sar, sarcalumenin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146620
    NCBI Gene: 106393
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4298080-4359680 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    381 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146620
 protein coding gene Chr16:4294843-4359772 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022463
 protein coding gene Chr16:959044-1027693 (-)
A/J MGP_AJ_G0022425
 protein coding gene Chr16:803680-869397 (-)
AKR/J MGP_AKRJ_G0022402
 protein coding gene Chr16:965522-1035037 (-)
BALB/cJ MGP_BALBcJ_G0022430
 protein coding gene Chr16:947331-1020486 (-)
C3H/HeJ MGP_C3HHeJ_G0022197
 protein coding gene Chr16:1001010-1065430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022879
 protein coding gene Chr16:1023521-1092605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020400
 protein coding gene Chr16:748357-811930 (-)
CAST/EiJ MGP_CASTEiJ_G0021723
 protein coding gene Chr16:985599-1052978 (-)
CBA/J MGP_CBAJ_G0022166
 protein coding gene Chr16:1109503-1174114 (-)
DBA/2J MGP_DBA2J_G0022297
 protein coding gene Chr16:913636-976400 (-)
FVB/NJ MGP_FVBNJ_G0022272
 protein coding gene Chr16:894877-959347 (-)
LP/J MGP_LPJ_G0022365
 protein coding gene Chr16:966305-1031526 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022294
 protein coding gene Chr16:967268-1042298 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022891
 protein coding gene Chr16:946290-1013495 (-)
PWK/PhJ MGP_PWKPhJ_G0021463
 protein coding gene Chr16:968137-1035711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021294
 protein coding gene Chr16:1036262-1103745 (-)
WSB/EiJ MGP_WSBEiJ_G0021772
 protein coding gene Chr16:962304-1030997 (-)



Homology
more
  • Human Ortholog
    SRL, sarcalumenin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRL, sarcalumenin
  • Synonyms
    SAR
  • Links
    NCBI Gene ID: 6345
    neXtProt AC: NX_Q86TD4
    UniProt: Q86TD4

  • Chr Location
    16p13.3; chr16:4189374-4242080 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit impaired calcium store functions in skeletal and cardiac muscle cells resulting in slow contraction and relaxation phases. Muscle also exhibits enhanced resistance to fatigue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    12
  • cDNA Data
    58
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022519 Ensembl Gene Model | MGI Sequence Detail 61601 C57BL/6J ±  kb
    transcript ENSMUST00000023161 Ensembl | MGI Sequence Detail 5000 Not Applicable  
    polypeptide ENSMUSP00000023161 Ensembl | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR045063 Dynamin, N-terminal
      IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
      IPR031692 EH domain-containing protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 58
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory