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Urb1 Gene Detail
Summary
  • Symbol
    Urb1
  • Name
    URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
  • Synonyms
    4921511H13Rik, 5730405K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146468
    NCBI Gene: 207932
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90548415-90607301 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 51.92 cM, cytoband C3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146468
protein coding gene Chr16:90548415-90607312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023029
protein coding gene Chr16:91719324-91780203 (-)
A/J MGP_AJ_G0022997
protein coding gene Chr16:87439581-87497753 (-)
AKR/J MGP_AKRJ_G0022967
protein coding gene Chr16:90071085-90128716 (-)
BALB/cJ MGP_BALBcJ_G0022999
protein coding gene Chr16:87960034-88019129 (-)
C3H/HeJ MGP_C3HHeJ_G0022760
protein coding gene Chr16:90639174-90697523 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023446
protein coding gene Chr16:94699824-94762358 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020948
protein coding gene Chr16:85138933-85199344 (-)
CAST/EiJ MGP_CASTEiJ_G0022279
protein coding gene Chr16:91187841-91246250 (-)
CBA/J MGP_CBAJ_G0022729
protein coding gene Chr16:98729857-98797280 (-)
DBA/2J MGP_DBA2J_G0022863
protein coding gene Chr16:87337339-87395641 (-)
FVB/NJ MGP_FVBNJ_G0022837
protein coding gene Chr16:86462619-86525818 (-)
LP/J MGP_LPJ_G0022933
protein coding gene Chr16:91408319-91473599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022858
protein coding gene Chr16:103303512-103365263 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023464
protein coding gene Chr16:90583387-90644157 (-)
PWK/PhJ MGP_PWKPhJ_G0022024
protein coding gene Chr16:87507252-87567067 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021854
protein coding gene Chr16:90147258-90206132 (-)
WSB/EiJ MGP_WSBEiJ_G0022331
protein coding gene Chr16:90819218-90878231 (-)



Homology
more
  • Human Ortholog
    URB1, URB1 ribosome biogenesis homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    URB1, URB1 ribosome biogenesis homolog
  • Synonyms
    C21orf108, NPA1
  • Links
    NCBI Gene ID: 9875
    neXtProt AC: NX_O60287
    UniProt: O60287

  • Chr Location
    21q22.11; chr21:32311018-32393012 (-)  GRCh38

Human Diseases
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  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039929 Ensembl Gene Model | MGI Sequence Detail 58887 C57BL/6J ±  kb
transcript ENSMUST00000140920 Ensembl | MGI Sequence Detail 7344 Not Applicable  
polypeptide ENSMUSP00000114717 Ensembl | MGI Sequence Detail 2277 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017130 nucleolar pre-ribosomal-associated protein 1
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR039844 Nucleolar pre-ribosomal-associated protein 1
    IPR032436 Nucleolar pre-ribosomal-associated protein 1, C-terminal domain
    IPR021714 Nucleolar pre-ribosomal-associated protein 1, N-terminal
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1923256, MGI:2652096
References
more
  • Summaries
    All 96
    Developmental Gene Expression 3
    Diseases 4
    Gene Ontology 3
    Phenotypes 71
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:344930 Shan L, et al., Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature. 2023 Mar;615(7952):526-534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory