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Txndc5 Gene Detail
Summary
  • Symbol
    Txndc5
  • Name
    thioredoxin domain containing 5
  • Synonyms
    ERp46, PC-TRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145316
    NCBI Gene: 105245
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:38684242-38712800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 18.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145316
 protein coding gene Chr13:38684055-38712800 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020473
 protein coding gene Chr13:36853058-36882409 (-)
A/J MGP_AJ_G0020427
 protein coding gene Chr13:35675460-35703568 (-)
AKR/J MGP_AKRJ_G0020405
 protein coding gene Chr13:36623657-36651632 (-)
BALB/cJ MGP_BALBcJ_G0020423
 protein coding gene Chr13:35777053-35805060 (-)
C3H/HeJ MGP_C3HHeJ_G0020222
 protein coding gene Chr13:36452675-36481461 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020856
 protein coding gene Chr13:38052476-38080738 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018443
 protein coding gene Chr13:33856938-33885382 (-)
CAST/EiJ MGP_CASTEiJ_G0019737
 protein coding gene Chr13:36222281-36259226 (-)
CBA/J MGP_CBAJ_G0020183
 protein coding gene Chr13:39654234-39685321 (-)
DBA/2J MGP_DBA2J_G0020305
 protein coding gene Chr13:35197090-35225378 (-)
FVB/NJ MGP_FVBNJ_G0020284
 protein coding gene Chr13:34726234-34754692 (-)
LP/J MGP_LPJ_G0020380
 protein coding gene Chr13:37098253-37126920 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020314
 protein coding gene Chr13:39746132-39775518 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020899
 protein coding gene Chr13:36195606-36223812 (-)
PWK/PhJ MGP_PWKPhJ_G0019492
 protein coding gene Chr13:35315977-35351745 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019323
 protein coding gene Chr13:34861750-34899734 (-)
WSB/EiJ MGP_WSBEiJ_G0019799
 protein coding gene Chr13:36544645-36572874 (-)



Homology
more
  • Human Ortholog
    TXNDC5, thioredoxin domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNDC5, thioredoxin domain containing 5
  • Synonyms
    ENDOPDI, ERP46, HCC2, HCC-2, PDIA15, STRF8, UNQ364
  • Links
    NCBI Gene ID: 81567
    neXtProt AC: NX_Q8NBS9
    UniProt: Q8NBS9

  • Chr Location
    6p24.3; chr6:7881517-7910788 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mcie homozygous for a null allele exhibit protection from isoproterenol-induced cardiac fibrosis and myocardial dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    23
  • cDNA Data
    12
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105245 NCBI Gene Model | MGI Sequence Detail 28559 C57BL/6J ±  kb
    transcript NM_145367 RefSeq | MGI Sequence Detail 2671 C57BL/6  
    polypeptide Q91W90 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345334 Xie H, et al., SUMOylation of ERp44 enhances Ero1alpha ER retention contributing to the pathogenesis of obesity and insulin resistance. Metabolism. 2023 Feb;139:155351
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory