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Tmem11 Gene Detail
Summary
  • Symbol
    Tmem11
  • Name
    transmembrane protein 11
  • Synonyms
    5730466P16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144726
    NCBI Gene: 216821
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60755278-60769864 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144726
 protein coding gene Chr11:60755278-60770098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018428
 protein coding gene Chr11:60790851-60805552 (-)
A/J MGP_AJ_G0018397
 protein coding gene Chr11:58551757-58566386 (-)
AKR/J MGP_AKRJ_G0018367
 protein coding gene Chr11:60398104-60412820 (-)
BALB/cJ MGP_BALBcJ_G0018368
 protein coding gene Chr11:58847035-58861927 (-)
C3H/HeJ MGP_C3HHeJ_G0018181
 protein coding gene Chr11:60348197-60363025 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018820
 protein coding gene Chr11:62714988-62735997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016466
 protein coding gene Chr11:55691091-55705876 (-)
CAST/EiJ MGP_CASTEiJ_G0017738
 protein coding gene Chr11:60453986-60468615 (-)
CBA/J MGP_CBAJ_G0018155
 protein coding gene Chr11:65438941-65453570 (-)
DBA/2J MGP_DBA2J_G0018264
 protein coding gene Chr11:58135119-58149904 (-)
FVB/NJ MGP_FVBNJ_G0018255
 protein coding gene Chr11:57806186-57820915 (-)
LP/J MGP_LPJ_G0018337
 protein coding gene Chr11:61364121-61378880 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018279
 protein coding gene Chr11:66496775-66512913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018861
 protein coding gene Chr11:60500061-60514690 (-)
PWK/PhJ MGP_PWKPhJ_G0017511
 protein coding gene Chr11:58717560-58731498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017301
 protein coding gene Chr11:60310530-60327020 (-)
WSB/EiJ MGP_WSBEiJ_G0017790
 protein coding gene Chr11:60118922-60133740 (-)



Homology
more
  • Human Ortholog
    TMEM11, transmembrane protein 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM11, transmembrane protein 11
  • Synonyms
    C17orf35, PM1, PMI
  • Links
    NCBI Gene ID: 8834
    neXtProt AC: NX_P17152
    UniProt: P17152

  • Chr Location
    17p11.2; chr17:21197954-21214176 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enhanced adult cardiomyocyte proliferation, with increased numbers of and smaller size of cardiomyocytes, and enhanced restoration of heart function after myocardial injury. Another allele shows eye and skin abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216821 NCBI Gene Model | MGI Sequence Detail 14587 C57BL/6J ±  kb
    transcript NM_001168507 RefSeq | MGI Sequence Detail 1511 C57BL/6  
    polypeptide Q8BK08 UniProt | EBI | MGI Sequence Detail 190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345326 Chen XZ, et al., TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA. Cell Death Differ. 2023 Jul;30(7):1786-1798
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory