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Nsrp1 Gene Detail
Summary
  • Symbol
    Nsrp1
  • Name
    nuclear speckle regulatory protein 1
  • Synonyms
    Ccdc55, NSpr70
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144305
    NCBI Gene: 237859
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76935118-76969261 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144305
 protein coding gene Chr11:76935118-76969263 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018743
 protein coding gene Chr11:77908546-77947094 (-)
A/J MGP_AJ_G0018709
 protein coding gene Chr11:74983953-75018438 (-)
AKR/J MGP_AKRJ_G0018679
 protein coding gene Chr11:77253055-77288463 (-)
BALB/cJ MGP_BALBcJ_G0018683
 protein coding gene Chr11:75365866-75400116 (-)
C3H/HeJ MGP_C3HHeJ_G0018496
 protein coding gene Chr11:77275387-77311486 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019134
 protein coding gene Chr11:80364957-80401485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016769
 protein coding gene Chr11:71973956-72007461 (-)
CAST/EiJ MGP_CASTEiJ_G0018050
 protein coding gene Chr11:77680988-77717442 (-)
CBA/J MGP_CBAJ_G0018466
 protein coding gene Chr11:83861469-83899450 (-)
DBA/2J MGP_DBA2J_G0018575
 protein coding gene Chr11:74573686-74608660 (-)
FVB/NJ MGP_FVBNJ_G0018565
 protein coding gene Chr11:74137371-74171912 (-)
LP/J MGP_LPJ_G0018646
 protein coding gene Chr11:78513278-78552004 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018591
 protein coding gene Chr11:84326080-84367048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019174
 protein coding gene Chr11:77467746-77504197 (-)
PWK/PhJ MGP_PWKPhJ_G0017821
 protein coding gene Chr11:75318306-75353195 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017612
 protein coding gene Chr11:77052743-77096540 (-)
WSB/EiJ MGP_WSBEiJ_G0018103
 protein coding gene Chr11:77283213-77318936 (-)



Homology
more
  • Human Ortholog
    NSRP1, nuclear speckle splicing regulatory protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSRP1, nuclear speckle splicing regulatory protein 1
  • Synonyms
    CCDC55, HSPC095, NEDSSBA, NSrp70
  • Links
    NCBI Gene ID: 84081
    neXtProt AC: NX_Q9H0G5
    UniProt: Q9H0G5

  • Chr Location
    17q11.2; chr17:30115521-30186475 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die prior to E6.5. Homozygous KO in lymphocytes affects alternative splicing of pre-mRNA splicing factors and other genes, which leads to reduced numbers of mature T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    39
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037958 Ensembl Gene Model | MGI Sequence Detail 34144 C57BL/6J ±  kb
transcript ENSMUST00000102494 Ensembl | MGI Sequence Detail 3114 Not Applicable  
polypeptide ENSMUSP00000099552 Ensembl | MGI Sequence Detail 542 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029652 nuclear speckle splicing regulatory protein 1
    (term hierarchy)
  • InterPro Domains
    IPR042816 Nuclear speckle splicing regulatory protein 1
    IPR018612 Nuclear speckle splicing regulatory protein 1, N-terminal
    IPR046850 Nuclear speckle splicing regulatory protein 1, RS-like domain
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144344
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:338811 Qu F, et al., Three-dimensional molecular architecture of mouse organogenesis. Nat Commun. 2023 Jul 31;14(1):4599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory