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Tmem263 Gene Detail
Summary
  • Symbol
    Tmem263
  • Name
    transmembrane protein 263
  • Synonyms
    AI597468
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143652
    NCBI Gene: 103266
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84938491-84953611 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143652
 protein coding gene Chr10:84938491-84956482 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017597
 protein coding gene Chr10:86004423-86019395 (+)
A/J MGP_AJ_G0017577
 protein coding gene Chr10:83077210-83092320 (+)
AKR/J MGP_AKRJ_G0017536
 protein coding gene Chr10:85391795-85406914 (+)
BALB/cJ MGP_BALBcJ_G0017540
 protein coding gene Chr10:83326843-83342385 (+)
C3H/HeJ MGP_C3HHeJ_G0017362
 protein coding gene Chr10:85477193-85493591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017997
 protein coding gene Chr10:88917731-88937341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015681
 protein coding gene Chr10:78897710-78964748 (+)
CAST/EiJ MGP_CASTEiJ_G0016929
 protein coding gene Chr10:85334066-85351095 (+)
CBA/J MGP_CBAJ_G0017332
 protein coding gene Chr10:92607283-92624113 (+)
DBA/2J MGP_DBA2J_G0017438
 protein coding gene Chr10:82220008-82235462 (+)
FVB/NJ MGP_FVBNJ_G0017432
 protein coding gene Chr10:81453618-81468729 (+)
LP/J MGP_LPJ_G0017510
 protein coding gene Chr10:86635776-86651810 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017460
 protein coding gene Chr10:94220046-94251100 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018034
 protein coding gene Chr10:85313480-85329285 (+)
PWK/PhJ MGP_PWKPhJ_G0016710
 protein coding gene Chr10:82089209-82105666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016499
 protein coding gene Chr10:83938577-83958168 (+)
WSB/EiJ MGP_WSBEiJ_G0016988
 protein coding gene Chr10:85299957-85315718 (+)



Homology
more
  • Human Ortholog
    TMEM263, transmembrane protein 263
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM263, transmembrane protein 263
  • Synonyms
    C12orf23
  • Links
    NCBI Gene ID: 90488
    neXtProt AC: NX_Q8WUH6
    UniProt: Q8WUH6

  • Chr Location
    12q23.3; chr12:106955719-106978778 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit severe postnatal growth failure, proportional dwarfism, and skeletal dysplasia with reduced bone mass and growth plate length. Serum calcium, insulin and glucose levels are reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103266 NCBI Gene Model | MGI Sequence Detail 15121 C57BL/6J ±  kb
    transcript NM_001013028 RefSeq | MGI Sequence Detail 3778 C57BL/6  
    polypeptide Q9DAM7 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 4
    References
    more
    • Summaries
      All 32
      Gene Ontology 1
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345905 Sarver DC, et al., Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition. Elife. 2024 Jan 19;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory