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Peds1 Gene Detail
Summary
  • Symbol
    Peds1
  • Name
    plasmanylethanolamine desaturase 1
  • Synonyms
    Tmem189
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142624
    NCBI Gene: 407243
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167485145-167503464 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142624
 protein coding gene Chr2:167484528-167531742 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026917
 protein coding gene Chr2:173398757-173459994 (-)
A/J MGP_AJ_G0026884
 protein coding gene Chr2:166252088-166309032 (-)
AKR/J MGP_AKRJ_G0026855
 protein coding gene Chr2:171215833-171267152 (-)
BALB/cJ MGP_BALBcJ_G0026893
 protein coding gene Chr2:166612345-166660457 (-)
C3H/HeJ MGP_C3HHeJ_G0026635
 protein coding gene Chr2:171587198-171636484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027340
 protein coding gene Chr2:178463452-178485087 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024711
 protein coding gene Chr2:159565073-159613183 (-)
CAST/EiJ MGP_CASTEiJ_G0026093
 protein coding gene Chr2:172052303-172104031 (-)
CBA/J MGP_CBAJ_G0026612
 protein coding gene Chr2:185018821-185076007 (-)
DBA/2J MGP_DBA2J_G0026750
 protein coding gene Chr2:165363945-165412156 (-)
FVB/NJ MGP_FVBNJ_G0026716
 protein coding gene Chr2:163902815-163952332 (-)
LP/J MGP_LPJ_G0026851
 protein coding gene Chr2:173417802-173472439 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026735
 protein coding gene Chr2:188376098-188427741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027397
 protein coding gene Chr2:171145625-171197909 (-)
PWK/PhJ MGP_PWKPhJ_G0025830
 protein coding gene Chr2:165038409-165088508 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025631
 protein coding gene Chr2:170094457-170144403 (-)
WSB/EiJ MGP_WSBEiJ_G0026166
 protein coding gene Chr2:172054218-172103873 (-)



Homology
more
  • Human Ortholog
    PEDS1, plasmanylethanolamine desaturase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEDS1, plasmanylethanolamine desaturase 1
  • Synonyms
    CarF, KUA, TMEM189
  • Links
    NCBI Gene ID: 387521
    neXtProt AC: NX_A5PLL7
    UniProt: A5PLL7

  • Chr Location
    20q13.13; chr20:50118254-50153734 (-)  GRCh38
  • Human Ortholog
    PEDS1-UBE2V1, PEDS1-UBE2V1 readthrough
  • Synonyms
    CROC1B, CROC-1B, KUA-UEV, TMEM189-UBE2V1
  • Links
    NCBI Gene ID: 387522
    neXtProt AC: NX_A5PLL7, NX_Q13404

  • Chr Location
    20q13.13; chr20:50081124-50153723 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack plasmanylethanolamine desaturase activity and show decreased body weight and severely reduced plasmalogen levels in all analyzed tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 407243 NCBI Gene Model | MGI Sequence Detail 18320 C57BL/6J ±  kb
    transcript NM_145538 RefSeq | MGI Sequence Detail 1700 C57BL/6  
    polypeptide Q99LQ7 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 6
    References
    more
    • Summaries
      All 33
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:70056 Franko J, et al., Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Biochim Biophys Acta. 2001 May 28;1519(1-2):70-7
    • Latest
      J:333103 Lackner K, et al., Alterations in ether lipid metabolism and the consequences for the mouse lipidome. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Jan 21;1868(4):159285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory