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Adprs Gene Detail
Summary
  • Symbol
    Adprs
  • Name
    ADP-ribosylserine hydrolase
  • Synonyms
    Adprhl2, Arh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140364
    NCBI Gene: 100206
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126210144-126215496 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 60.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140364
 protein coding gene Chr4:126209840-126215496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028778
 protein coding gene Chr4:127990697-127996354 (-)
A/J MGP_AJ_G0028737
 protein coding gene Chr4:122953071-122958729 (-)
AKR/J MGP_AKRJ_G0028690
 protein coding gene Chr4:126332200-126337856 (-)
BALB/cJ MGP_BALBcJ_G0028760
 protein coding gene Chr4:123528739-123534395 (-)
C3H/HeJ MGP_C3HHeJ_G0028474
 protein coding gene Chr4:126399134-126404790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029202
 protein coding gene Chr4:132881947-132887725 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026475
 protein coding gene Chr4:116099884-116105891 (-)
CAST/EiJ MGP_CASTEiJ_G0027907
 protein coding gene Chr4:124505971-124511665 (-)
CBA/J MGP_CBAJ_G0028440
 protein coding gene Chr4:136082861-136088517 (-)
DBA/2J MGP_DBA2J_G0028589
 protein coding gene Chr4:123407175-123412831 (-)
FVB/NJ MGP_FVBNJ_G0028556
 protein coding gene Chr4:122063266-122068922 (-)
LP/J MGP_LPJ_G0028690
 protein coding gene Chr4:128277189-128282846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028582
 protein coding gene Chr4:141116741-141122397 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029240
 protein coding gene Chr4:126686291-126691947 (-)
PWK/PhJ MGP_PWKPhJ_G0027628
 protein coding gene Chr4:119894473-119900796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027454
 protein coding gene Chr4:122513438-122519090 (-)
WSB/EiJ MGP_WSBEiJ_G0027987
 protein coding gene Chr4:126787547-126793203 (-)



Homology
more
  • Human Ortholog
    ADPRS, ADP-ribosylserine hydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADPRS, ADP-ribosylserine hydrolase
  • Synonyms
    ADPRHL2, ARH3, CONDSIAS
  • Links
    NCBI Gene ID: 54936
    neXtProt AC: NX_Q9NX46
    UniProt: Q9NX46

  • Chr Location
    1p34.3; chr1:36088892-36093932 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADPRS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit increased susceptibility to ischemic brain injury with increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100206 NCBI Gene Model | MGI Sequence Detail 5353 C57BL/6J ±  kb
    transcript NM_133883 RefSeq | MGI Sequence Detail 1368 C57BL/6  
    polypeptide Q8CG72 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:83667 Glowacki G, et al., The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Protein Sci. 2002 Jul;11(7):1657-70
    • Latest
      J:291285 Mashimo M, et al., PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells. JCI Insight. 2019 Feb 21;4(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory