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Abtb2 Gene Detail
Summary
  • Symbol
    Abtb2
  • Name
    ankyrin repeat and BTB domain containing 2
  • Synonyms
    BPOZ-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139365
    NCBI Gene: 99382
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103396655-103548768 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139365
 protein coding gene Chr2:103396655-103548768 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026205
 protein coding gene Chr2:105551671-105707539 (+)
A/J MGP_AJ_G0026166
 protein coding gene Chr2:101197624-101349930 (+)
AKR/J MGP_AKRJ_G0026147
 protein coding gene Chr2:103943222-104099331 (+)
BALB/cJ MGP_BALBcJ_G0026175
 protein coding gene Chr2:101486447-101640772 (+)
C3H/HeJ MGP_C3HHeJ_G0025926
 protein coding gene Chr2:104285735-104437831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026626
 protein coding gene Chr2:109086473-109245562 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024017
 protein coding gene Chr2:96876747-97028383 (+)
CAST/EiJ MGP_CASTEiJ_G0025391
 protein coding gene Chr2:104757732-104913567 (+)
CBA/J MGP_CBAJ_G0025904
 protein coding gene Chr2:112819248-112972862 (+)
DBA/2J MGP_DBA2J_G0026041
 protein coding gene Chr2:100759893-100912258 (+)
FVB/NJ MGP_FVBNJ_G0026003
 protein coding gene Chr2:99759126-99910157 (+)
LP/J MGP_LPJ_G0026144
 protein coding gene Chr2:105682963-105840653 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026029
 protein coding gene Chr2:116752428-116909333 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026680
 protein coding gene Chr2:104156044-104313363 (+)
PWK/PhJ MGP_PWKPhJ_G0025126
 protein coding gene Chr2:100271983-100425504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024927
 protein coding gene Chr2:103377041-103528218 (+)
WSB/EiJ MGP_WSBEiJ_G0025458
 protein coding gene Chr2:104864025-105018039 (+)



Homology
more
  • Human Ortholog
    ABTB2, ankyrin repeat and BTB domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABTB2, ankyrin repeat and BTB domain containing 2
  • Synonyms
    ABTB2A, BTBD22
  • Links
    NCBI Gene ID: 25841
    neXtProt AC: NX_Q8N961
    UniProt: Q8N961

  • Chr Location
    11p13; chr11:34150987-34358010 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in delayed response to induced acute liver damage and reduced liver regeneration after induced damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1064
  • Tissues
    110
  • cDNA Data
    56
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 99382 NCBI Gene Model | MGI Sequence Detail 152114 C57BL/6J ±  kb
transcript NM_178890 RefSeq | MGI Sequence Detail 4595 Not Specified  
polypeptide Q7TQI7 UniProt | EBI | MGI Sequence Detail 1024 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 56
    Primer pair 1
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 9
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:321365 Knoedler JR, et al., A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory