Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Mmetm1Cge
Name:	membrane metallo endopeptidase; targeted mutation 1, Craig Gerard
MGI ID:	MGI:2137696
Synonyms:	NEP-
Gene:	Mme  Location: Chr3:63202632-63291134 bp, + strand  Genetic Position: Chr3, 29.97 cM
Alliance:	Mmetm1Cge page

Germline Transmission:	Earliest citation of germline transmission: J:70516
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced 0.6kb of sequence containing exon 13 and part of intron 13. Northern blot analysis using a cDNA probe for the active site region, exons 14 - 20, did not detect message in renal tissue from homozygous mutant pups. (J:70516)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mme Mutation:	61 strains or lines available

Original:	J:70516 Lu B, et al., Neutral endopeptidase modulation of septic shock. J Exp Med. 1995 Jun 1;181(6):2271-5
All:	32 reference(s)