Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmp6tm1Rob
Name:	bone morphogenetic protein 6; targeted mutation 1, Elizabeth J Robertson
MGI ID:	MGI:2136985
Gene:	Bmp6  Location: Chr13:38529098-38684283 bp, + strand  Genetic Position: Chr13, 18.15 cM
Alliance:	Bmp6tm1Rob page

Germline Transmission:	Earliest citation of germline transmission: J:48561
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A ~1 kb genomic fragment containing 84 bp of exon 2 was replaced with a neomycin selection cassette. These sequences encode a portion of the pro-polypeptide region. RNAse protection assays on total RNA derived from kidney and brain of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:48561)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmp6 Mutation:	30 strains or lines available

Original:	J:48561 Solloway MJ, et al., Mice lacking Bmp6 function. Dev Genet. 1998;22(4):321-39
All:	20 reference(s)