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Irs1tm1Tka
Targeted Allele Detail
Summary
Symbol: Irs1tm1Tka
Name: insulin receptor substrate 1; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2136643
Synonyms: IRS-1-
Gene: Irs1  Location: Chr1:82210822-82269137 bp, - strand  Genetic Position: Chr1, 42.0 cM, cytoband C5
Alliance: Irs1tm1Tka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21373
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin cassette disrupted the first exon of the gene, preventing the production of stable mRNA transcripts. No transcript was detected in hepatic tissues of homozygous null mice by Northern blot analysis. Western blots of liver homogenates showed no detectable protein. (J:21373)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs1 Mutation:  51 strains or lines available
References
Original:  J:21373 Tamemoto H, et al., Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 [see comments]. Nature. 1994 Nov 10;372(6502):182-6
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory