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Rxratm3Ipc
Targeted Allele Detail
Summary
Symbol: Rxratm3Ipc
Name: retinoid X receptor alpha; targeted mutation 3, Pierre Chambon
MGI ID: MGI:2136273
Synonyms: HS23.26Cre, RXRalpha af1
Gene: Rxra  Location: Chr2:27566452-27652969 bp, + strand  Genetic Position: Chr2, 19.38 cM
Alliance: Rxratm3Ipc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69853
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: Deletion of exon 2 (with the exception of its splicing acceptor site), intron 2, and 102 bp of exon 3. The resulting protein is truncated from amino acid 11-132l. This region contains the autonomous AF-1 activation function and several phosphorylation sites. This is a null mutation for the alpha 2 and 3 isoforms. (J:69853)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  30 strains or lines available
Notes
A second line of mice (BL19) was established where the floxed selectable marker was excised by crossing heterozygotes with a transgenic mouse expressing CRE under the control of the CMV promoter. Identical phenotypic observations were made in both lines of mice.
References
Original:  J:69853 Mascrez B, et al., Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha. Development. 2001 Jun;128(11):2049-62
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory