Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fgfr4tm1Cxd
Name:	fibroblast growth factor receptor 4; targeted mutation 1, Chu-Xia Deng
MGI ID:	MGI:2135678
Synonyms:	FR4KO
Gene:	Fgfr4  Location: Chr13:55300631-55316572 bp, + strand  Genetic Position: Chr13, 29.8 cM
Alliance:	Fgfr4tm1Cxd page

Germline Transmission:	Earliest citation of germline transmission: J:50677
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin cassette into exon 6, which encodes the IgII domain. No mRNA was detected in liver from homozygous mutant animals as assayed by Northern blot. Immunohistochemical analysis failed to detect protein in lungs from homozygous mutant mice. (J:50677)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr4 Mutation:	39 strains or lines available

Original:	J:50677 Weinstein M, et al., FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998 Sep;125(18):3615-23
All:	29 reference(s)