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Park7 Gene Detail
Summary
  • Symbol
    Park7
  • Name
    Parkinson disease (autosomal recessive, early onset) 7
  • Synonyms
    DJ-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135637
    NCBI Gene: 57320
  • Alliance
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:150981590-150994378 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.52 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135637
protein coding gene Chr4:150981590-150998894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029157
protein coding gene Chr4:154923651-154942232 (-)
A/J MGP_AJ_G0029122
protein coding gene Chr4:148403060-148421373 (-)
AKR/J MGP_AKRJ_G0029070
protein coding gene Chr4:152467530-152488708 (-)
BALB/cJ MGP_BALBcJ_G0029138
protein coding gene Chr4:148897815-148917606 (-)
C3H/HeJ MGP_C3HHeJ_G0028859
protein coding gene Chr4:153034187-153052594 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029587
protein coding gene Chr4:160482642-160503444 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026833
protein coding gene Chr4:140795093-140812036 (-)
CAST/EiJ MGP_CASTEiJ_G0028272
protein coding gene Chr4:150312496-150330677 (-)
CBA/J MGP_CBAJ_G0028821
protein coding gene Chr4:165245061-165267174 (-)
DBA/2J MGP_DBA2J_G0028970
protein coding gene Chr4:148484633-148501927 (-)
FVB/NJ MGP_FVBNJ_G0028934
protein coding gene Chr4:147630016-147647143 (-)
LP/J MGP_LPJ_G0029060
protein coding gene Chr4:154850799-154869233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028961
protein coding gene Chr4:168365939-168386102 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029619
protein coding gene Chr4:152995684-153013975 (-)
PWK/PhJ MGP_PWKPhJ_G0027992
protein coding gene Chr4:144522697-144540134 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027826
protein coding gene Chr4:147241473-147257971 (-)
WSB/EiJ MGP_WSBEiJ_G0028352
protein coding gene Chr4:153135153-153152000 (-)



Homology
more
  • Human Ortholog
    PARK7, Parkinsonism associated deglycase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARK7, Parkinsonism associated deglycase
  • Synonyms
    DJ1, DJ-1, GATD2, HEL-S-67p
  • Links
    NCBI Gene ID: 11315
    neXtProt AC: NX_Q99497
    UniProt: Q99497

  • Chr Location
    1p36.23; chr1:7954291-7985505 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Park7 mouse models; 5 with human PARK7 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 7 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced evoked dopamine overflow in the striatum, resulting primarily from increased dopamine uptake. Mice show hyopactivity, absent long-term depression in medium spiny neurons and decreased sensitivity of nigral neurons to dopamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57320 NCBI Gene Model | MGI Sequence Detail 12789 C57BL/6J ±  kb
    transcript NM_020569 RefSeq | MGI Sequence Detail 920 C57BL/6  
    polypeptide Q99LX0 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      cDNA 198

      Microarray probesets 4
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 33
      Phenotypes 140
    • Earliest
      J:52842 Nagakubo D, et al., DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13
    • Latest
      J:342354 Chien CH, et al., Growth of B16F10 cells is enhanced in DJ-1-deficiency pancreas. Biochem Biophys Res Commun. 2023 Nov 19;682:359-364

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory