Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fcer2atm1Max
Name:	Fc receptor, IgE, low affinity II, alpha polypeptide; targeted mutation 1, Max-Planck-Institut fur Immunbiologie
MGI ID:	MGI:1934672
Synonyms:	CD23-, Fc epsilon RII
Gene:	Fcer2a  Location: Chr8:3731737-3744175 bp, - strand  Genetic Position: Chr8, 1.92 cM, cytoband A1
Alliance:	Fcer2atm1Max page

Germline Transmission:	Earliest citation of germline transmission: J:18952
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exons 3 and 4. Northern blot analysis did not detect mRNA in homozygous mutant spleen. Flow cytometric analysis did not detect membrane-bound protein in homozygous mutant spleen. (J:18952)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcer2a Mutation:	24 strains or lines available

Original:	J:18952 Yu P, et al., Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994 Jun 30;369(6483):753-6
All:	16 reference(s)