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Prnptm1Miy
Targeted Allele Detail
Summary
Symbol: Prnptm1Miy
Name: prion protein; targeted mutation 1, Tsutomu Miyamoto
MGI ID: MGI:1934272
Synonyms: Nagasaki, Ngsk Prnp0, Prnp-, PrP
Gene: Prnp  Location: Chr2:131751848-131780349 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance: Prnptm1Miy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69186
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding sequence of the gene was replaced with a neomycin cassette. No mRNA was detected in the brains of homozyogous mutant mice by either Northern blotting or by in situ hybridization. (J:69186)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  150 strains or lines available
References
Original:  J:69186 Sakaguchi S, et al., Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent. J Virol. 1995 Dec;69(12):7586-92
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory