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Il1raptm1Roml
Targeted Allele Detail
Summary
Symbol: Il1raptm1Roml
Name: interleukin 1 receptor accessory protein; targeted mutation 1, Mark A Labow
MGI ID: MGI:1934017
Synonyms: IL-1RAcP-
Gene: Il1rap  Location: Chr16:26400454-26548867 bp, + strand  Genetic Position: Chr16, 18.21 cM, cytoband B2
Alliance: Il1raptm1Roml page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68065
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons D1 and part of D2A. These exons encode the first Ig domain and part of the second Ig domain. Northern blot analysis revealed that a truncated mRNA was produced from this allele, but equilibrium binding studies demonstrated that no protein was present on the cell surface of primary mouse embryo fibroblasts (PMEFs) derived from homozygous mice. (J:68065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il1rap Mutation:  53 strains or lines available
References
Original:  J:68065 Cullinan EB, et al., IL-1 receptor accessory protein is an essential component of the IL-1 receptor. J Immunol. 1998 Nov 15;161(10):5614-20
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory