Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Cdkn1ctm1Kat Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi MGI ID: MGI:1933758 Synonyms: p57-, p57Kip2(-) Gene: Cdkn1c  Location: Chr7:143012076-143014735 bp, - strand  Genetic Position: Chr7, 88.22 cM Alliance: Cdkn1ctm1Kat page

Representative testes, seminal vesicles, and uteri from wild-type, Cdkn1ctm1Kat/Cdkn1c+, and Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+ mice at 7 weeks of age Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:61190
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the entire coding region, including exons 1, 2, 3 and part of exon 4 with a neomycin cassette. (J:61190) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	25 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:	19 strains or lines available

Original:	J:61190 Takahashi K, et al., Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J Biochem. 2000 Jan;127(1):73-83
All:	13 reference(s)