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Lfngtm1Rjo
Targeted Allele Detail
Summary
Symbol: Lfngtm1Rjo
Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Randy L Johnson
MGI ID: MGI:1933737
Synonyms: Lfng-
Gene: Lfng  Location: Chr5:140593096-140601300 bp, + strand  Genetic Position: Chr5, 79.15 cM
Alliance: Lfngtm1Rjo page
Irregular sacral segmentation in Hes7tm1Kag/Hes7tm1Kag mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48859
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 1 of the Lnfg gene, including the translational start site, the signal sequence, and a putative processing site. The authors predict the mutant allele would be a null mutation, and report that Lnfg mRNA is not detected in homozygous mutant embryos. (J:48859)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 78 assay results
In Structures Affected by this Mutation: 16 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lfng Mutation:  32 strains or lines available
References
Original:  J:48859 Evrard YA, et al., lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23;394(6691):377-81
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory