Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tgfatm1Unc Name: transforming growth factor alpha; targeted mutation 1, University of North Carolina MGI ID: MGI:1933208 Synonyms: TGFalpha-, Tgfatm1Dcl Gene: Tgfa  Location: Chr6:86172205-86252701 bp, + strand  Genetic Position: Chr6, 37.62 cM Alliance: Tgfatm1Unc page

Phenotypes of Egfrwa2/EgfrWa5 and Tgfatm1Unc/Tgfatm1Unc EgfrWa5/+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:4605
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into exon 4. Homozygous mutant mice do not express mRNA from this allele. Protein was undetectable in homozygous mutant macrophages in a radioimmunoassay. (J:4605) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tgfa Mutation:	17 strains or lines available

Original:	J:4605 Luetteke NC, et al., TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell. 1993 Apr 23;73(2):263-78
All:	15 reference(s)