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Siglece Gene Detail
Summary
  • Symbol
    Siglece
  • Name
    sialic acid binding Ig-like lectin E
  • Synonyms
    mSiglec-E, Siglec5, Siglecl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932475
    NCBI Gene: 83382
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43300494-43309585 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932475
 protein coding gene Chr7:43300494-43309585 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032135
 protein coding gene Chr7:43679630-43688517 (-)
A/J MGP_AJ_G0032120
 protein coding gene Chr7:42778031-42786835 (-)
AKR/J MGP_AKRJ_G0032050
 protein coding gene Chr7:44157247-44166215 (-)
BALB/cJ MGP_BALBcJ_G0032125
 protein coding gene Chr7:42895088-42904279 (-)
C3H/HeJ MGP_C3HHeJ_G0031841
 protein coding gene Chr7:44659388-44668599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032609
 protein coding gene Chr7:45877013-45887311 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029632
 protein coding gene Chr7:44908775-44917911 (-)
CAST/EiJ MGP_CASTEiJ_G0031171
 protein coding gene Chr7:35833962-35846382 (-)
CBA/J MGP_CBAJ_G0031810
 protein coding gene Chr7:47328852-47344247 (-)
DBA/2J MGP_DBA2J_G0031959
 protein coding gene Chr7:42585961-42595148 (-)
FVB/NJ MGP_FVBNJ_G0031920
 protein coding gene Chr7:42297959-42306945 (-)
LP/J MGP_LPJ_G0032038
 protein coding gene Chr7:44410183-44419177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031956
 protein coding gene Chr7:46267189-46275994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032629
 protein coding gene Chr7:43281685-43290762 (-)
PWK/PhJ MGP_PWKPhJ_G0030892
 protein coding gene Chr7:36029253-36038340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030731
 protein coding gene Chr7:31330767-31339583 (-)
WSB/EiJ MGP_WSBEiJ_G0031285
 protein coding gene Chr7:43827898-43837273 (-)



Homology
more
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12
  • Synonyms
    S2V, SIGLECL1, Siglec-XII, SLG
  • Links
    NCBI Gene ID: 89858
    neXtProt AC: NX_Q96PQ1
    UniProt: Q96PQ1

  • Chr Location
    19q13.41; chr19:51491227-51501800 (-)  GRCh38
  • Human Ortholog
    SIGLEC7, sialic acid binding Ig like lectin 7
  • Synonyms
    AIRM1, AIRM-1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC19P, SIGLEC-7, SIGLECP2
  • Links
    NCBI Gene ID: 27036
    neXtProt AC: NX_Q9Y286
    UniProt: Q9Y286

  • Chr Location
    19q13.41; chr19:51142299-51153526 (+)  GRCh38
  • Human Ortholog
    SIGLEC8, sialic acid binding Ig like lectin 8
  • Synonyms
    SAF2, SIGLEC-8, SIGLEC8L
  • Links
    NCBI Gene ID: 27181
    neXtProt AC: NX_Q9NYZ4
    UniProt: Q9NYZ4

  • Chr Location
    19q13.41; chr19:51450847-51458456 (-)  GRCh38
  • Human Ortholog
    SIGLEC9, sialic acid binding Ig like lectin 9
  • Synonyms
    CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
  • Links
    NCBI Gene ID: 27180
    neXtProt AC: NX_Q9Y336
    UniProt: Q9Y336

  • Chr Location
    19q13.41; chr19:51119778-51136651 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a knock-in allele that destroys the sialic acid binding site exhibit increased neutrophil and macrophage recruitment in an LPS-induced model of acute lung ariway inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83382 NCBI Gene Model | MGI Sequence Detail 9092 C57BL/6J ±  kb
transcript NM_031181 RefSeq | MGI Sequence Detail 1849 Not Specified  
polypeptide Q91Y57 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:67541 Yu Z, et al., mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J. 2001 Feb 1;353(Pt 3):483-92
  • Latest
    J:343619 Schmassmann P, et al., Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma. Sci Transl Med. 2023 Jul 19;15(705):eadf5302
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory