Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Xpctm1Brd
Name:	xeroderma pigmentosum, complementation group C; targeted mutation 1, Allan Bradley
MGI ID:	MGI:1931883
Synonyms:	XPC-, xpcm1
Gene:	Xpc  Location: Chr6:91466287-91492870 bp, - strand  Genetic Position: Chr6, 40.55 cM, cytoband D
Alliance:	Xpctm1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:28708
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An hprt expression cassette replaced four exons and introduced a frameshift and two stop codons downstream of the mutation. RT-PCR studies of embryonic fibroblast cells detected an aberrant short Xpc transcript in homozygous mutant mice. (J:28708)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xpc Mutation:	34 strains or lines available

Original:	J:28708 Sands AT, et al., High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature. 1995 Sep 14;377(6545):162-5
All:	11 reference(s)