Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Crkltm1Imo
Name:	v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Akira Imamoto
MGI ID:	MGI:1931805
Synonyms:	Crkol -
Gene:	Crkl  Location: Chr16:17269851-17305298 bp, + strand  Genetic Position: Chr16, 10.82 cM
Alliance:	Crkltm1Imo page

Germline Transmission:	Earliest citation of germline transmission: J:67826
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP flanked neo cassette was inserted in the first coding exon. Western blot analysis confirmed that no protein was expressed in homozygous mutant embryos. (J:67826)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:	15 strains or lines available

Original:	J:67826 Guris DL, et al., Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nat Genet. 2001 Mar;27(3):293-8
All:	7 reference(s)