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Rhoq Gene Detail
Summary
  • Symbol
    Rhoq
  • Name
    ras homolog family member Q
  • Synonyms
    Arhq, TC10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931553
    NCBI Gene: 104215
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87270539-87307497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 56.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931553
protein coding gene Chr17:87270510-87307497 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024096
protein coding gene Chr17:90315871-90352834 (+)
A/J MGP_AJ_G0024055
protein coding gene Chr17:87407013-87443871 (+)
AKR/J MGP_AKRJ_G0024024
protein coding gene Chr17:88879617-88916191 (+)
BALB/cJ MGP_BALBcJ_G0024056
protein coding gene Chr17:87255145-87292565 (+)
C3H/HeJ MGP_C3HHeJ_G0023821
protein coding gene Chr17:89741545-89779581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024501
protein coding gene Chr17:93442711-93481593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021940
protein coding gene Chr17:82565454-82602461 (+)
CAST/EiJ MGP_CASTEiJ_G0023300
protein coding gene Chr17:90574683-90611921 (+)
CBA/J MGP_CBAJ_G0023795
protein coding gene Chr17:97370617-97410174 (+)
DBA/2J MGP_DBA2J_G0023923
protein coding gene Chr17:85857317-85894293 (+)
FVB/NJ MGP_FVBNJ_G0023889
protein coding gene Chr17:85356962-85395770 (+)
LP/J MGP_LPJ_G0024007
protein coding gene Chr17:91101114-91139855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023917
protein coding gene Chr17:97273023-97311530 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024546
protein coding gene Chr17:89396748-89433430 (+)
PWK/PhJ MGP_PWKPhJ_G0023045
protein coding gene Chr17:85490509-85540935 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022856
protein coding gene Chr17:86150392-86186699 (+)
WSB/EiJ MGP_WSBEiJ_G0023366
protein coding gene Chr17:90240545-90277309 (+)



Homology
more
  • Human Ortholog
    RHOQ, ras homolog family member Q
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOQ, ras homolog family member Q
  • Synonyms
    ARHQ, HEL-S-42, RASL7A, TC10, TC10A
  • Links
    NCBI Gene ID: 23433
    neXtProt AC: NX_P17081
    UniProt: P17081

  • Chr Location
    2p21; chr2:46541806-46584688 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal brain development but show reduced axon regeneration after injury in both the peripheral and central nervous systems. Cultured hippocampal neurons display reduced axon elongation without affecting polarization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104215 NCBI Gene Model | MGI Sequence Detail 36959 C57BL/6J ±  kb
    transcript NM_145491 RefSeq | MGI Sequence Detail 4159 ZRU/MplStud  
    polypeptide Q8R527 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 141
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
    • Latest
      J:308705 Koinuma S, et al., TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. J Neurochem. 2021 May;157(4):1196-1206

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory