Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Agrntm2Jrs
Name:	agrin; targeted mutation 2, Joshua R Sanes
MGI ID:	MGI:1930978
Synonyms:	agrndeltaY
Gene:	Agrn  Location: Chr4:156249747-156281945 bp, - strand  Genetic Position: Chr4, 88.55 cM
Alliance:	Agrntm2Jrs page

Germline Transmission:	Earliest citation of germline transmission: J:55407
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of exon 28, encoding the "y" alternative splice exon as follows: A lox-P flanked neomycin cassette replaced exon 28, and was excised in ES cells prior to blastocyst injection via Cre-mediated recombination. The final allele has a single lox-P site in place of the exon. (J:55407) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agrn Mutation:	101 strains or lines available

Original:	J:55407 Burgess RW, et al., Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction. Neuron. 1999 May;23(1):33-44
All:	1 reference(s)