Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Stat1tm1Dlv
Name:	signal transducer and activator of transcription 1; targeted mutation 1, David E Levy
MGI ID:	MGI:1930947
Synonyms:	STAT-, Stat1-, STAT1-, Stat1 KO
Gene:	Stat1  Location: Chr1:52158599-52201024 bp, + strand  Genetic Position: Chr1, 26.81 cM
Alliance:	Stat1tm1Dlv page

Germline Transmission:	Earliest citation of germline transmission: J:31325
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. (J:31325)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Stat1tm1Dlv

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:	72 strains or lines available

Original:	J:31325 Durbin JE, et al., Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996 Feb 9;84(3):443-50
All:	231 reference(s)