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Insm2 Gene Detail
Summary
  • Symbol
    Insm2
  • Name
    insulinoma-associated 2
  • Synonyms
    mlt 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930787
    NCBI Gene: 56856
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:55646212-55648818 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 24.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930787
 protein coding gene Chr12:55646212-55648871 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019751
 protein coding gene Chr12:54655131-54658232 (+)
A/J MGP_AJ_G0019710
 protein coding gene Chr12:52696276-52699377 (+)
AKR/J MGP_AKRJ_G0019685
 protein coding gene Chr12:54356577-54359678 (+)
BALB/cJ MGP_BALBcJ_G0019690
 protein coding gene Chr12:53053204-53056305 (+)
C3H/HeJ MGP_C3HHeJ_G0019495
 protein coding gene Chr12:54421483-54424581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020142
 protein coding gene Chr12:56291108-56294209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017762
 protein coding gene Chr12:51199065-51202193 (+)
CAST/EiJ MGP_CASTEiJ_G0019047
 protein coding gene Chr12:49284598-49287688 (+)
CBA/J MGP_CBAJ_G0019464
 protein coding gene Chr12:58281978-58285079 (+)
DBA/2J MGP_DBA2J_G0019580
 protein coding gene Chr12:52606479-52609580 (+)
FVB/NJ MGP_FVBNJ_G0019568
 protein coding gene Chr12:51903932-51907043 (+)
LP/J MGP_LPJ_G0019652
 protein coding gene Chr12:54651361-54654462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019606
 protein coding gene Chr12:59832035-59835134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020176
 protein coding gene Chr12:53804300-53807399 (+)
PWK/PhJ MGP_PWKPhJ_G0018814
 protein coding gene Chr12:46958779-46961965 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018607
 protein coding gene Chr12:48207333-48210419 (+)
WSB/EiJ MGP_WSBEiJ_G0019098
 protein coding gene Chr12:54314134-54317240 (+)



Homology
more
  • Human Ortholog
    INSM2, INSM transcriptional repressor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INSM2, INSM transcriptional repressor 2
  • Synonyms
    IA6, IA-6, mlt1
  • Links
    NCBI Gene ID: 84684
    neXtProt AC: NX_Q96T92
    UniProt: Q96T92

  • Chr Location
    14q13.2; chr14:35534164-35537054 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out mice exhibit increased fasting blood glucose levels, reduced glucose tolerance and insulin and C-peptide level, and reduced female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    64
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56856 NCBI Gene Model | MGI Sequence Detail 2607 C57BL/6J ±  kb
    transcript NM_020287 RefSeq | MGI Sequence Detail 2607 C57BL/6  
    polypeptide Q9JMC2 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:67331 Tateno M, et al., Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 2001 Feb 1;61(3):1144-53
    • Latest
      J:334014 Li ZM, et al., Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice. Cell Cycle. 2022 Nov;21(21):2255-2267
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory