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Brca1tm1Cxd
Targeted Allele Detail
Summary
Symbol: Brca1tm1Cxd
Name: breast cancer 1, early onset; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1930612
Synonyms: Brca111-, Brca1delta11, Brca1Ko, brca1Ko22
Gene: Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Alliance: Brca1tm1Cxd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51834
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Deletion of 330 bp of intron 10 and 407 bp of exon 11 and replacement with a neomycin cassette. (J:51834)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Brca1tm1Cxd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  113 strains or lines available
References
Original:  J:51834 Shen SX, et al., A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998 Dec 17;17(24):3115-24
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory