Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bdnftm1Lfr
Name:	brain derived neurotrophic factor; targeted mutation 1, Louis F Reichardt
MGI ID:	MGI:1930110
Synonyms:	BDNF-, BDNFneo
Gene:	Bdnf  Location: Chr2:109505045-109557352 bp, + strand  Genetic Position: Chr2, 56.63 cM
Alliance:	Bdnftm1Lfr page

Germline Transmission:	Earliest citation of germline transmission: J:67231
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of a large region of the coding region and replacement with a neomycin cassette. Deleted sequences include residues required for prohomrone processing and interactions of mature neurotrophins with Trk receptors and with Ngfr. (J:67231) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:	39 strains or lines available

Original:	J:67231 Jones KR, et al., Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell. 1994 Mar 25;76(6):989-99
All:	15 reference(s)