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Mcm3ap Gene Detail
Summary
  • Symbol
    Mcm3ap
  • Name
    minichromosome maintenance complex component 3 associated protein
  • Synonyms
    GANP, mKIAA0572
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930089
    NCBI Gene: 54387
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:76304761-76351691 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930089
 protein coding gene Chr10:76304736-76351693 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017384
 protein coding gene Chr10:76712837-76768178 (+)
A/J MGP_AJ_G0017361
 protein coding gene Chr10:74059542-74114520 (+)
AKR/J MGP_AKRJ_G0017322
 protein coding gene Chr10:76060132-76111811 (+)
BALB/cJ MGP_BALBcJ_G0017321
 protein coding gene Chr10:74267053-74317987 (+)
C3H/HeJ MGP_C3HHeJ_G0017145
 protein coding gene Chr10:76136516-76192324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017779
 protein coding gene Chr10:79423099-79473582 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015469
 protein coding gene Chr10:70515063-70561932 (+)
CAST/EiJ MGP_CASTEiJ_G0016715
 protein coding gene Chr10:76454386-76504750 (+)
CBA/J MGP_CBAJ_G0017117
 protein coding gene Chr10:82527024-82584579 (+)
DBA/2J MGP_DBA2J_G0017222
 protein coding gene Chr10:73368827-73416147 (+)
FVB/NJ MGP_FVBNJ_G0017214
 protein coding gene Chr10:72525760-72573770 (+)
LP/J MGP_LPJ_G0017295
 protein coding gene Chr10:77209271-77255615 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017243
 protein coding gene Chr10:84587593-84640108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017818
 protein coding gene Chr10:76117316-76171383 (+)
PWK/PhJ MGP_PWKPhJ_G0016499
 protein coding gene Chr10:73212884-73260456 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016282
 protein coding gene Chr10:75347995-75398298 (+)
WSB/EiJ MGP_WSBEiJ_G0016778
 protein coding gene Chr10:76095817-76149044 (+)



Homology
more
  • Human Ortholog
    MCM3AP, minichromosome maintenance complex component 3 associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM3AP, minichromosome maintenance complex component 3 associated protein
  • Synonyms
    GANP, MAP80, PNRIID, SAC3
  • Links
    NCBI Gene ID: 8888
    neXtProt AC: NX_O60318
    UniProt: O60318

  • Chr Location
    21q22.3; chr21:46235133-46286297 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die by E12.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    74
  • cDNA Data
    122
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001150 Ensembl Gene Model | MGI Sequence Detail 46931 C57BL/6J ±  kb
    transcript ENSMUST00000170795 Ensembl | MGI Sequence Detail 6427 Not Applicable  
    polypeptide ENSMUSP00000125960 Ensembl | MGI Sequence Detail 1971 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010244 germinal-center associated nuclear protein
      (term hierarchy)
    • EC
      2.3.1.48
    • InterPro Domains
      IPR031910 Germinal-centre associated nuclear protein, CID domain
      IPR031907 Germinal-centre associated nuclear protein, MCM3AP domain
      IPR031908 Germinal-centre associated nuclear protein, nucleoporin homology domain
      IPR034265 MCM3AP, RNA recognition motif
      IPR000717 Proteasome component (PCI) domain
      IPR035979 RNA-binding domain superfamily
      IPR045107 SAC3/GANP/THP3
      IPR005062 SAC3/GANP/THP3, conserved domain
    Molecular
    Reagents
    less
    • All nucleic 126
      Genomic 1
      cDNA 122
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 8
      Phenotypes 40
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341136 Muza PM, et al., Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. iScience. 2023 Feb 17;26(2):106073
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory