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Klrc3 Gene Detail
Summary
  • Symbol
    Klrc3
  • Name
    killer cell lectin-like receptor subfamily C, member 3
  • Synonyms
    NKG2E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929720
    NCBI Gene: 58179
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:129616027-129620300 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929720
 protein coding gene Chr6:129613226-129620474 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031355
 protein coding gene Chr6:133310195-133314420 (-)
A/J MGP_AJ_G0031326
 protein coding gene Chr6:128213982-128218219 (-)
AKR/J MGP_AKRJ_G0031254
 protein coding gene Chr6:131713700-131717937 (-)
BALB/cJ MGP_BALBcJ_G0031333
 protein coding gene Chr6:127861547-127865784 (-)
C3H/HeJ MGP_C3HHeJ_G0031057
 protein coding gene Chr6:131909269-131913506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031792
 protein coding gene Chr6:136823002-136829777 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030435
 protein coding gene Chr6:132152294-132177956 (-)
CBA/J MGP_CBAJ_G0031017
 protein coding gene Chr6:142203921-142208158 (-)
DBA/2J MGP_DBA2J_G0031174
 protein coding gene Chr6:127166366-127170603 (-)
FVB/NJ MGP_FVBNJ_G0031124
 protein coding gene Chr6:126055142-126059413 (-)
LP/J MGP_LPJ_G0031254
 protein coding gene Chr6:133535515-133539752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031162
 protein coding gene Chr6:146083371-146087644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031825
 protein coding gene Chr6:131793436-131797691 (-)
PWK/PhJ MGP_PWKPhJ_G0030153
 protein coding gene Chr6:125451752-125456079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029982
 protein coding gene Chr6:129802876-129805482 (-)
WSB/EiJ MGP_WSBEiJ_G0030523
 protein coding gene Chr6:132212763-132216989 (-)



Homology
more
  • Human Ortholog
    KLRC3, killer cell lectin like receptor C3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRC3, killer cell lectin like receptor C3
  • Synonyms
    NKG2E, NKG2-E
  • Links
    NCBI Gene ID: 3823
    neXtProt AC: NX_Q07444
    UniProt: Q07444

  • Chr Location
    12p13.2; chr12:10412315-10420595 (-)  GRCh38
  • Human Ortholog
    KLRC4, killer cell lectin like receptor C4
  • Synonyms
    NKG2F, NKG2-F
  • Links
    NCBI Gene ID: 8302
    neXtProt AC: NX_O43908
    UniProt: O43908

  • Chr Location
    12p13.2; chr12:10407384-10409757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033027 Ensembl Gene Model | MGI Sequence Detail 4274 C57BL/6J ±  kb
    transcript ENSMUST00000071149 Ensembl | MGI Sequence Detail 715 Not Applicable  
    polypeptide ENSMUSP00000071147 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 18
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:66316 Vance RE, et al., Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999 Dec 20;190(12):1801-12
    • Latest
      J:311543 Ferez M, et al., Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. J Exp Med. 2021 May 3;218(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory