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Ikbke Gene Detail
Summary
  • Symbol
    Ikbke
  • Name
    inhibitor of kappaB kinase epsilon
  • Synonyms
    IKKepsilon, IKK-i
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929612
    NCBI Gene: 56489
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131182337-131207339 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929612
 protein coding gene Chr1:131182080-131207344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016452
 protein coding gene Chr1:134677593-134703243 (-)
A/J MGP_AJ_G0016435
 protein coding gene Chr1:129703455-129729259 (-)
AKR/J MGP_AKRJ_G0016400
 protein coding gene Chr1:133515047-133540430 (-)
BALB/cJ MGP_BALBcJ_G0016395
 protein coding gene Chr1:130031184-130056456 (-)
C3H/HeJ MGP_C3HHeJ_G0016221
 protein coding gene Chr1:133651629-133678545 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016856
 protein coding gene Chr1:139684685-139713193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014570
 protein coding gene Chr1:122837537-122863880 (-)
CAST/EiJ MGP_CASTEiJ_G0015801
 protein coding gene Chr1:132652032-132675611 (-)
CBA/J MGP_CBAJ_G0016193
 protein coding gene Chr1:144489608-144517553 (-)
DBA/2J MGP_DBA2J_G0016300
 protein coding gene Chr1:128668589-128694453 (-)
FVB/NJ MGP_FVBNJ_G0016299
 protein coding gene Chr1:127297162-127323342 (-)
LP/J MGP_LPJ_G0016371
 protein coding gene Chr1:135996500-136021687 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016324
 protein coding gene Chr1:150254119-150282028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016892
 protein coding gene Chr1:133281476-133306695 (-)
PWK/PhJ MGP_PWKPhJ_G0015587
 protein coding gene Chr1:127625133-127650659 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015374
 protein coding gene Chr1:132208925-132235490 (-)
WSB/EiJ MGP_WSBEiJ_G0015863
 protein coding gene Chr1:133262357-133288665 (-)



Homology
more
  • Human Ortholog
    IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon
  • Synonyms
    IKKE, IKK-E, IKK-i, IKKI
  • Links
    NCBI Gene ID: 9641
    neXtProt AC: NX_Q14164
    UniProt: Q14164

  • Chr Location
    1q32.1; chr1:206470476-206496889 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    24
  • cDNA Data
    33
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56489 NCBI Gene Model | MGI Sequence Detail 25003 C57BL/6J ±  kb
    transcript NM_019777 RefSeq | MGI Sequence Detail 3203 NOD  
    polypeptide Q9R0T8 UniProt | EBI | MGI Sequence Detail 717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138621
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 43
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345060 Gao B, et al., Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis. Sci Adv. 2024 Feb 9;10(6):eadk2285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory