About   Help   FAQ
Erbb3tm2Cbm
Targeted Allele Detail
Summary
Symbol: Erbb3tm2Cbm
Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 2, Carmen Birchmeier
MGI ID: MGI:1929598
Synonyms: erbB3-, Erbb3KO2
Gene: Erbb3  Location: Chr10:128403392-128425504 bp, - strand  Genetic Position: Chr10, 77.1 cM
Alliance: Erbb3tm2Cbm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43515
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin gene was fused to an exon encoding extracellular sequences of the protein, introducing termination codons in all three reading frames. No protein is produced from this allele. (J:43515)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb3 Mutation:  47 strains or lines available
References
Original:  J:43515 Riethmacher D, et al., Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 1997 Oct 16;389(6652):725-30
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory