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Litaf Gene Detail
Summary
  • Symbol
    Litaf
  • Name
    LPS-induced TN factor
  • Synonyms
    3222402J11Rik, N4WBP3, Nedd4 WW domain-binding protein 3, TBX1 protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929512
    NCBI Gene: 56722
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10777137-10810985 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 6.28 cM, cytoband B1-B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929512
 protein coding gene Chr16:10777137-10884021 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022518
 protein coding gene Chr16:7798767-7914468 (-)
A/J MGP_AJ_G0022480
 protein coding gene Chr16:7371045-7478283 (-)
AKR/J MGP_AKRJ_G0022456
 protein coding gene Chr16:7707621-7817699 (-)
BALB/cJ MGP_BALBcJ_G0022484
 protein coding gene Chr16:7502787-7612511 (-)
C3H/HeJ MGP_C3HHeJ_G0022251
 protein coding gene Chr16:7788908-7902097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022933
 protein coding gene Chr16:7958965-8075584 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020453
 protein coding gene Chr16:7523751-7637813 (-)
CAST/EiJ MGP_CASTEiJ_G0021778
 protein coding gene Chr16:7811389-7925284 (-)
CBA/J MGP_CBAJ_G0022220
 protein coding gene Chr16:8310736-8432584 (-)
DBA/2J MGP_DBA2J_G0022351
 protein coding gene Chr16:7377619-7485695 (-)
FVB/NJ MGP_FVBNJ_G0022327
 protein coding gene Chr16:7363257-7477045 (-)
LP/J MGP_LPJ_G0022419
 protein coding gene Chr16:7752196-7866503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022349
 protein coding gene Chr16:8007591-8120075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022946
 protein coding gene Chr16:7652404-7764555 (-)
PWK/PhJ MGP_PWKPhJ_G0021518
 protein coding gene Chr16:7592374-7700717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021348
 protein coding gene Chr16:7720697-7835378 (-)
WSB/EiJ MGP_WSBEiJ_G0021826
 protein coding gene Chr16:7743435-7860766 (-)



Homology
more
  • Human Ortholog
    LITAF, lipopolysaccharide induced TNF factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LITAF, lipopolysaccharide induced TNF factor
  • Synonyms
    PIG7, SIMPLE, TP53I7
  • Links
    NCBI Gene ID: 9516
    neXtProt AC: NX_Q99732
    UniProt: Q99732

  • Chr Location
    16p13.13; chr16:11547722-11640317 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Litaf mouse models; 1 with human LITAF associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous ablation of this gene in macrophages results in reduced cytokine secretion in response to LPS stimulation, and increased resistance to LPS-induced septic shock. Knockout and certain mutations result in lysosome and endosome morphological anomalies, leading to exosome secretion defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    52
  • cDNA Data
    189
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56722 NCBI Gene Model | MGI Sequence Detail 33849 C57BL/6J ±  kb
transcript NM_019980 RefSeq | MGI Sequence Detail 2240 C57BL/6  
polypeptide Q9JLJ0 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009843 lipopolysaccharide-induced tumor necrosis factor-alpha factor
    (term hierarchy)
  • InterPro Domains
    IPR037519 LITAF domain containing protein
    IPR006629 LPS-induced tumour necrosis factor alpha factor
Molecular
Reagents
less
  • All nucleic 195
    cDNA 191
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:1913928, MGI:2146720
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory