About   Help   FAQ
Rybp Gene Detail
Summary
  • Symbol
    Rybp
  • Name
    RING1 and YY1 binding protein
  • Synonyms
    2410018J24Rik, DEDAF, MGC:62213
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929059
    NCBI Gene: 56353
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:100205526-100264319 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 46.62 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929059
 protein coding gene Chr6:100205526-100264446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031085
 protein coding gene Chr6:102232418-102303136 (-)
A/J MGP_AJ_G0031054
 protein coding gene Chr6:98327151-98386372 (-)
AKR/J MGP_AKRJ_G0030985
 protein coding gene Chr6:101015867-101077524 (-)
BALB/cJ MGP_BALBcJ_G0031065
 protein coding gene Chr6:98301623-98361669 (-)
C3H/HeJ MGP_C3HHeJ_G0030643
 protein coding gene Chr6:83332007-83393469 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031524
 protein coding gene Chr6:104799447-104860688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028688
 protein coding gene Chr6:96154507-96208945 (-)
CAST/EiJ MGP_CASTEiJ_G0030172
 protein coding gene Chr6:101259766-101327753 (-)
CBA/J MGP_CBAJ_G0030751
 protein coding gene Chr6:108827699-108894512 (-)
DBA/2J MGP_DBA2J_G0030904
 protein coding gene Chr6:97457260-97516464 (-)
FVB/NJ MGP_FVBNJ_G0030858
 protein coding gene Chr6:96637585-96692931 (-)
LP/J MGP_LPJ_G0030984
 protein coding gene Chr6:102276493-102339493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030892
 protein coding gene Chr6:112596388-112658417 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031551
 protein coding gene Chr6:100933467-100996505 (-)
PWK/PhJ MGP_PWKPhJ_G0029888
 protein coding gene Chr6:96478008-96537974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029716
 protein coding gene Chr6:99818136-99883185 (-)
WSB/EiJ MGP_WSBEiJ_G0030256
 protein coding gene Chr6:101435829-101502744 (-)



Homology
more
  • Human Ortholog
    RYBP, RING1 and YY1 binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RYBP, RING1 and YY1 binding protein
  • Synonyms
    AAP1, APAP-1, DEDAF, YEAF1
  • Links
    NCBI Gene ID: 23429
    neXtProt AC: NX_Q8N488
    UniProt: Q8N488

  • Chr Location
    3p13; chr3:72371825-72446623 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice initiate implantation but fail to complete decidualization and display early embryonic lethality. A subset of heterozygotes show forebrain overgrowth, delayed neural tube closure, exencephaly, failed optic fissure closure, malformed lenses, and retinal/optic nerve colobomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    106
  • cDNA Data
    10
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56353 NCBI Gene Model | MGI Sequence Detail 58794 C57BL/6J ±  kb
    transcript NM_019743 RefSeq | MGI Sequence Detail 4376 C57BL/6  
    polypeptide Q8CCI5 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920901
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 14
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:65786 Garcia E, et al., RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999 Jun 15;18(12):3404-18
    • Latest
      J:335625 Liu C, et al., USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Sci Adv. 2023 May 19;9(20):eade3888
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory