About   Help   FAQ
Vapb Gene Detail
Summary
  • Symbol
    Vapb
  • Name
    vesicle-associated membrane protein, associated protein B and C
  • Synonyms
    D2Abb2e, VAMP-associated protein 33b, VAP33b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928744
    NCBI Gene: 56491
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:173579378-173626132 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 97.37 cM, cytoband H3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928744
 protein coding gene Chr2:173579304-173626132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026961
 protein coding gene Chr2:180045543-180100227 (+)
A/J MGP_AJ_G0026928
 protein coding gene Chr2:172463929-172511997 (+)
AKR/J MGP_AKRJ_G0026899
 protein coding gene Chr2:177667042-177713191 (+)
BALB/cJ MGP_BALBcJ_G0026937
 protein coding gene Chr2:172864022-172909380 (+)
C3H/HeJ MGP_C3HHeJ_G0026679
 protein coding gene Chr2:178047325-178094733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027384
 protein coding gene Chr2:185221200-185267167 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024753
 protein coding gene Chr2:165691077-165734624 (+)
CAST/EiJ MGP_CASTEiJ_G0026138
 protein coding gene Chr2:178770326-178815842 (+)
CBA/J MGP_CBAJ_G0026656
 protein coding gene Chr2:192138028-192185576 (+)
DBA/2J MGP_DBA2J_G0026794
 protein coding gene Chr2:171553386-171600208 (+)
FVB/NJ MGP_FVBNJ_G0026760
 protein coding gene Chr2:170187865-170232640 (+)
LP/J MGP_LPJ_G0026895
 protein coding gene Chr2:179961891-180017210 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026779
 protein coding gene Chr2:195054332-195102159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027441
 protein coding gene Chr2:177687667-177737952 (+)
PWK/PhJ MGP_PWKPhJ_G0025874
 protein coding gene Chr2:171368245-171419152 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025674
 protein coding gene Chr2:176716539-176763108 (+)
WSB/EiJ MGP_WSBEiJ_G0026210
 protein coding gene Chr2:178640025-178693556 (+)



Homology
more
  • Human Ortholog
    VAPB, VAMP associated protein B and C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAPB, VAMP associated protein B and C
  • Synonyms
    ALS8, VAMP-B, VAP-B
  • Links
    NCBI Gene ID: 9217
    neXtProt AC: NX_O95292
    UniProt: O95292

  • Chr Location
    20q13.32; chr20:58389229-58451101 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human VAPB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing. Mice homozygous for another knock-out allele exhibit hypotonia, impaired coordination in older mice and mild tremors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56491 NCBI Gene Model | MGI Sequence Detail 46755 C57BL/6J ±  kb
    transcript NM_019806 RefSeq | MGI Sequence Detail 6958 ZRU/MplStud  
    polypeptide Q9QY76 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-34262, MGI:106568, MGI:2138863, MGI:2139066, MGI:2139072, MGI:2139546
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
    • Latest
      J:297784 Yamanaka T, et al., Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. Sci Rep. 2020 May 6;10(1):7610
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory